The purpose of this Partnership strategy framework is to guide the process of forming and maintaining strategic partnerships in public health. The approach is comprehensive, beginning with organizational self-assessment before starting a partnership and progressing through creating and maintaining a partnership, with analysis and reassessment integrated. The Partnership strategy framework is intended for use at any level of partnership, national, state, or local, and in any size partnership, from a single partner to a coalition. It can also be utilized at any stage of the partnership process, whether an organization is considering partnering or is already a part of a mature, well-established partnership.